Endodontic failures can be attributable to inadequacies in cleaning, shaping, and obturation, iatrogenic events, or reinfection of the root canal system when the coronal seal is lost after completion of root canal treatment. Regardless of the initial cause, the sum of all causes is microleakage.
References
1. Ruddle, C. Pathways of the Pulp, 8th edition, Mosby, 2002P

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