Answer: a,c,d
a. The highly vascular cancellous bone can deliver dramatic vasopressor response when concentrations higher than 1:100,00 of vasoconstrictor are used.
b. All intraosseous injections should be preceeded by delivery of anesthetic agent in the mucco-buccal fold to prevent discomfort during penetration of the
cortical plate. Block anesthesia is not required. (this is the point)
c. The bone at the angle of the mandible is thick and penetration can be difficult, therefore it should be avoided
d. One carpule of anesthetic agent maximum is adequate for profound anesthesia.

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