Answer is C
NSAIDs will increase the effectiveness of anticoagulants. NSAIDs may increase warafin’s effect on INR and exacerbate the adverse renal effects of ACE inhibitors. It may increase risk of GI ulceration when used with corticosteroids. Lithium, methotrexate and cyclosporine levels may be increased. CYP2C8 and 2C9 enzyme substrate interactions can occur. Avoid ethanol intake. Pregnancy risk factor is C and D in the third trimester. It may be taken while breast-feeding. Peak serum concentration occurs 1-2 hours after ingestion. Contraindications are hypersensitivity to NSAIDs, aspirin or other NSAIDs.
NSAIDs are broken down in the kidneys.
NSAIDs inhibit prostaglandin formation by decreasing the cyclooxygenase.
CNS disruption, confusion, agitation, or hallucinations are seen with high doses.
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