Oral Pathology MCQ Answer 1

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Answer is D

Microscopically, Ewing's sarcoma is composed of sheets of
uniform, small, round cells with a well-defined nuclear outline and
indistinct cellular borders. Mitotic activity is usually not
prominent. Perivascular bearing of neoplastic cells is commonly
seen,can show variable histological patterns namely, diffuse,
lobular, filigree, trabecular, globoid, and pseudo rosette formation

Ewing sarcoma is a malignant round-cell tumor, a rare disease in which cancer cells are found in the bone or in soft tissue. It is the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11 .
Ewing sarcoma occurs most frequently in male teenagers, with a male/female ratio of 1.6:1 Because almost all patients with apparently localized disease at diagnosis have occult metastatic disease, multidrug chemotherapy (often including ifosfamide and etoposide) as well as local disease control with surgery and/or radiation is indicated in the treatment of all patients